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. Author manuscript; available in PMC: 2011 Sep 21.
Published in final edited form as: Bioorg Med Chem Lett. 2009 May 3;19(12):3209–3213. doi: 10.1016/j.bmcl.2009.04.110

Table 1.

Structures and activities of analogs 14.graphic file with name nihms-113891-t0001.jpg

Cmpd R mGluR5a IC50 (μM) % Glu Maxb
10 graphic file with name nihms-113891-t0002.jpg 1.54 2.64
14a graphic file with name nihms-113891-t0003.jpg 1.18 2.69
14b graphic file with name nihms-113891-t0004.jpg >30 ND
14c graphic file with name nihms-113891-t0005.jpg 5.02 2.39
14d graphic file with name nihms-113891-t0006.jpg >10 56.2
14e graphic file with name nihms-113891-t0007.jpg 5.24 4.23
14f graphic file with name nihms-113891-t0008.jpg >10 52.1
14g graphic file with name nihms-113891-t0009.jpg >30 ND
14h graphic file with name nihms-113891-t0010.jpg >10 26.1
14i graphic file with name nihms-113891-t0011.jpg 0.82 1.12
14j graphic file with name nihms-113891-t0012.jpg >10 40.6
a

IC50s are average of three determinations.

b

Determined at 30 μM test compound. ND, not determined.