Table 4.
Overall Association of Pulmonary Surfactant Protein B with Atherosclerotic Phenotypes and Mortality
| Unadjusted | Adjusted | |||
|---|---|---|---|---|
| OR [95% CI] | P-value | OR [95% CI] | P-value | |
| CAC > 10 | N = 2485 | |||
| log SP-B* | 1.54 [1.41-1.69] | <0.0001 | 1.10 [0.97-1.25] | 0.15 |
| Q1 | 1.0 (referent) | 1.0 (referent) | ||
| Q2 | 1.62 [1.18-2.24] | 0.003 | 1.13 [0.78-1.65] | 0.52 |
| Q3 | 2.57 [1.90-3.46] | <0.0001 | 1.13 [0.78-1.62] | 0.52 |
| Q4 | 3.75 [2.80-5.03] | <0.0001 | 1.33 [0.91-1.94] | 0.14 |
| Former smoking | 1.27 [0.94-1.73] | 0.13 | ||
| Current Smoking | 2.63 [1.81-3.83] | <0.0001 | ||
| Pack-years* | 1.04 [0.93-1.16] | 0.54 | ||
| AP | N = 2296 | |||
| log SP-B* | 1.60 [1.47-1.75] | <0.0001 | 1.24 [1.11-1.38] | <0.0001 |
| Q1 | 1.0 (referent) | 1.0 (referent) | ||
| Q2 | 1.70 [1.31-2.19] | <0.0001 | 1.32 [1.00-1.74] | 0.05 |
| Q3 | 2.39 [1.87-3.06] | <0.0001 | 1.44 [1.09-1.89] | 0.01 |
| Q4 | 3.84 [3.01-4.92] | <0.0001 | 1.87 [1.39-2.51] | <0.0001 |
| Former Smoking | 1.28 [0.99-1.66] | 0.06 | ||
| Current Smoking | 1.36 [1.00-1.84] | 0.05 | ||
| Pack-years* | 1.21 [1.08-1.37] | 0.002 | ||
| HR [95% CI] | P-value | HR [95% CI] | P-value | |
| Overall Death | N = 2788 | |||
| log SP-B* | 1.57 [1.35-1.83] | <0.0001 | 1.20 [1.00-1.46] | 0.05 |
| Q1 | 1.0 (referent) | 1.0 (referent) | ||
| Q2 | 1.30 [0.62-2.73] | 0.49 | 0.94 [0.45-1.99] | 0.87 |
| Q3 | 3.57 [1.92-6.63] | <0.0001 | 1.70 [0.90-3.25] | 0.10 |
| Q4 | 4.60 [2.51-8.44] | <0.0001 | 1.85 [0.95-3.59] | 0.07 |
| Former Smoking | 1.84 [1.12-3.03[ | 0.02 | ||
| Current Smoking | 2.38 [1.37-4.14] | 0.002 | ||
| Pack-years* | 0.96 [0.82-1.12] | 0.60 | ||
| CV Death | N = 2788 | |||
| log SP-B* | 1.46 [1.15-1.85] | 0.002 | 1.16 [0.86-1.56] | 0.32 |
| Q1 | 1.0 (referent) | 1.0 (referent) | ||
| Q2 | 1.44 [0.54-3.87] | 0.47 | 1.08 [0.40-2.94] | 0.87 |
| Q3 | 2.61 [1.08-6.28] | 0.03 | 1.32 [0.53-3.31] | 0.56 |
| Q4 | 2.97 [1.25-7.07] | 0.01 | 1.30 [0.50-3.38] | 0.59 |
| Former Smoking | 1.17 [0.55-2.49] | 0.69 | ||
| Current Smoking | 1.49 [0.63-3.54] | 0.36 | ||
| Pack-years* | 0.98 [0.74-1.30] | 0.88 | ||
CAC=coronary artery calcium; AP=aortic plaque; SP-B=pulmonary surfactant protein B
Adjusted models include age, sex, ethnicity, hypertension, diabetes, hypercholesterolemia, low HDL-C, hypertriglyceridemia, BMI, smoking status (current, former, never smoker), and pack-years smoked.
*
OR per 1 SD increment in SP-B
Odds ratio for CAC and AP derived from logistic regression models. Hazard ratios for all-cause death (n=125) and CV death (n=52) derived from Cox-proportional hazards models.