Figure 3.

Average Shannon entropy 〈D〉_i versus average relative entropy 〈S〉_{i +1} for each season between 1992–1993 (i = 0) and 2008–2009 (i = 16). For each season i, a set of amino acid positions j with Shannon entropy D_i,j greater than 0.1 are chosen. For all the j in this set of positions, 〈D〉_i is the average of the Shannon entropy D_i,j values and 〈S〉_{i +1} is the average of relative entropy S_{i +1,j} values. Horizontal and vertical error bars are the standard errors of Shannon entropy and relative entropy, respectively. The solid line, 〈S〉_{i +1} = 1.82〈D〉_i−0.23, is a least squares fit of 〈D〉_i to 〈S〉_{i +1} (i = 0,2, …,16). A strong correlation with R² = 0.50 exists between 〈D〉_i and 〈S〉_{i +1} excluding the point (0.22,1.38) with N_i = 1, which has a large standard error of the relative entropy S_{i +1,j}. Using the same method, 〈D〉_i and 〈S〉_{i +1} are calculated from a neutral evolution model, i = 51–100, and plotted. No visible correlation exists between 〈D〉_i and 〈S〉_{i +1} from the neutral evolution model (crosses). Open squares represent H3 data.