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. 2011 Aug 1;20(20):4025–4040. doi: 10.1093/hmg/ddr331

Figure 4.

Figure 4.

Differential expression of known and novel miRNAs in normal, uninvolved psoriatic and involved psoriatic skin. (A) Venn diagram indicating the number of differentially expressed miRNAs that were ±2-fold differentially expressed in any of the three comparisons: PP/NN, PP/PN, PN/NN. (B) Heat map showing hierarchical clustering of skin samples on the basis of 98 differentially expressed miRNAs. (C) qRT-PCR levels of differentially expressed miR-135b, miR-431, miR-675* and novel #117/miR-203-AS in 10 NN, 10 PN and 10 PP patients. Lines indicate matched uninvolved and involved samples from the same patient (***P < 0.001, **P < 0.01,*P < 0.05). Relative expression was calculated with respect to the endogenous snoRNA Z30 (see Materials and Methods). NN, normal skin; PN, uninvolved psoriatic skin; PP, involved psoriatic skin.