Table 3.
Measures of insulin sensitivity and insulin secretion in participants with habitual short sleep and matched control subjects who sleep >6 h/day
| Sleep >6 h/d | Short sleep | P value* | P value† | |
|---|---|---|---|---|
| Primary outcome measure | ||||
| ISI | 11.4 ± 5.6 | 7.7 ± 4.3 | 0.033 | 0.013 |
| Secondary end points | ||||
| HOMA-IR | 0.46 ± 0.28 | 0.81 ± 0.70 | 0.009# | 0.001# |
| Fasting insulin (pmol/L) | 25 ± 15 | 44 ± 38 | 0.010# | 0.001# |
| 3-h AUC insulin (pmol ⋅ L−1 ⋅ min−1) | 36,992 ± 13,306 | 52,895 ± 30,208 | 0.050 | 0.008 |
| CIR | 1,490 ± 1,124 | 2,570 ± 2,370 | 0.116 | 0.007 |
Data are mean ± SD (n = 15 in each group). AUC, area under the curve during the OGTT.
*P values based on ANCOVA with sleep group (short vs. control) as a between-subject factor controlling for daily time spent in physical activity of moderate-and-vigorous intensity, which was included as a covariate.
†P values based on ANCOVA as in * with additional control for participant age, which was included as a covariate.
#Square root–transformed data used for comparison.