Table 1. RLR detection of viral genera and viral RNA genome type.

Viruses detected by RIG-I

Paramyxoviridae (-) ssRNA, NS

Sendai virus (Kato, Sato et al. 2005; Yoneyama, Kikuchi et al. 2005)

Newcastle disease virus (Kato, Sato et al. 2005)

Respiratory syncytial virus (Loo, Fornek et al. 2008)

Measles (Plumet, Herschke et al. 2007)

Nipah (Habjan, Andersson et al. 2008)

Human parainfluenza 5 mRNA (Luthra, Sun et al. 2011)

Rhabdoviridae (-) ssRNA, NS

Vesicular stomatitis virus (Kato, Sato et al. 2005; Yoneyama, Kikuchi et al. 2005)

Rabies virus (Hornung, Ellegast et al. 2006)

Orthomyxoviridae (-) ssRNA NS

Influenza A (Kato, Takeuchi et al. 2006)

Influenza B (Loo, Fornek et al. 2008)

Filoviridae (-) ssRNA NS

Ebola (Habjan, Andersson et al. 2008)

Arenaviridae (-) ssRNA S

Lassa (Habjan, Andersson et al. 2008)

Lymphocytic choriomeningitis virus (Zhou, Cerny et al. 2010)

Bunyaviridae (-) ssRNA S

Rift Valley fever virus (Habjan, Andersson et al. 2008)

Flaviviridae (+) ssRNA NS

Hepatitis C virus (Sumpter, Loo et al. 2005; Saito, Hirai et al. 2007)

Coronaviridae (+) ssRNA NS

Murine hepatitis virus (Roth-Cross, Bender et al. 2008)

Caliciviridae (+) ssRNA NS

Murine norovirus-1 (McCartney, Thackray et al. 2008)

DNA viruses

Epstein-Barr virus EBER (Samanta, Iwakiri et al. 2006)

Myxoma virus (Wang, Gao et al. 2008)

Viruses detected by MDA5

Picornaviridae (+) ssRNA NS

Encephalomyocarditis virus (Gitlin, Barchet et al. 2006; Kato, Takeuchi et al. 2006)

Theiler's virus (Kato, Takeuchi et al. 2006)

Mengo virus (Kato, Takeuchi et al. 2006)

DNA viruses

Vaccinia virus (Pichlmair, Schulz et al. 2009)

Flaviviruses detected by both MDA5 and RIG-I

Flaviviridae

Japanese encephalitis virus (Kato, Takeuchi et al. 2006)

Dengue virus (Loo, Fornek et al. 2008)

West Nile virus (Fredericksen, Keller et al. 2008)

Reoviridae dsRNA S

Reovirus (Kato, Takeuchi et al. 2008; Loo, Fornek et al. 2008)

Annotations regarding the virus genome include the nucleotide composition e.g. single-stranded (ssRNA) or double-stranded RNA (dsRNA); positive (+) or negative (-) sense genomic orientation, and segmentation (S) versus non-segmentation (NS).