Table 1. The kinetic and biological properties of the PFKFB3 inhibitors.

Inhibitor	IC50 [µM]	Ki [µM]	Inhibition	GI50[µM]
N4A	2.97±0.16	1.29±0.26	Competitive to Fru-6-P	14.2±1.5
YN1	0.67±0.08	0.24±0.03	Competitive to Fru-6-P	8.2±0.8
YZ9	0.18	0.094	Competitive to Fru-6-P	2.7±0.2