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. 2011 Sep 21;6(9):e24874. doi: 10.1371/journal.pone.0024874

Figure 5. PKC signaling pathway positively regulates ST8SiaII and ST8SiaIV mRNA expression levels.

Figure 5

Graphs illustrating the effect of the pharmacological inhibition of different signaling pathways on ST8SiaII (A) and ST8SiaIV (B) mRNA levels. Both ST8SiaII and ST8SiaIV mRNA levels are prematurely down-regulated in chelerythryne (CHE)-treated samples, compared to controls (Two-Way ANOVA, by post hoc Dunn's test, *p<0.05). TTX-induced increase in ST8SiaII mRNA levels (*p<0.05) does not occur in presence of CHE. Indeed, ST8SiaII levels in CHE+TTX cultures are not significantly different from those found in controls (Two-Way ANOVA, by post hoc Dunn's test, p>0.05). Neither ST8SiaII (A) or ST8SiaIV (A) mRNA levels are affected by the application of U0126, KN-62, KT5823 and KT5720 (Two-Way ANOVA, by post hoc Dunn's test, p>0.05). Graphs are plotted as explained in Figure 2.