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. 2011 Sep 21;6(9):e25192. doi: 10.1371/journal.pone.0025192

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de Jong et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Chemical structures of 15d-PGJ₂ (15-deoxy-Δ^12,14-Prostaglandin J₂) and its analog CAY-10410 (9,10-dihydro-15-deoxy-Δ^12,14-Prostaglandin J₂). Asterisk indicates the electrophilic carbon atoms which might be involved in Michael addition reaction. Panel (A) and (B) show the concentration-dependent effects of 15d-PGJ₂, CAY-10410 and ciglitazone on the deacetylase activity of SIRT1 and HDAC1, respectively using in vitro enzyme assays. ^#P<0.01 versus ciglitazone, ^†p<0.05 and ^††p<0.01 versus CAY-10410. (D) Effect of CAY-10410 on the cell viability of A2780 and A2780/AD cells as measured with an alamar blue assay. (E) Treatment with CAY-10410 (2.5 µM) did not induce cell transformation after 48 h incubation. Magnification, 200×.