FIG. 2.

Therapeutic control of established tumors. Groups of eight mice were injected with 10⁶ A20 cells. When the tumors reached an average size of 200 μl, the mice were immunized intramuscularly with 3×10¹⁰ VP of Ad-A20 or control DPBS. Control of established tumors by immunization with Ad-A20 was not achieved. Although the tumor growth in Ad-A20-immunized mice appeared to be delayed (A) the ultimate survival rates of the immunized and control mice were equivalent (B). There were no significant differences in tumor sizes or survival between immunized and control.