Fig. 4.

Response time courses for basic lifespan indirect response models corresponding to the monoexponential pharmacokinetic function at indicated doses. a Stimulation of k_in0 (Eqs. 9 and 35). b Inhibition of k_in0 (Eqs. 10 and 35). c Stimulation of n/T_R (inhibition of T_R) (Eqs. 7 and 30). d Inhibition of n/T_R (stimulation of T_R) (Eqs. 8 and 30). The parameter values used for simulations were k_in0 = R₀/T_R, R₀ = 100, T_R = 24, I_max = S_max = 1, and IC₅₀ = SC₅₀ = 100