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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2010 Nov 24;38(2):179–204. doi: 10.1007/s10928-010-9183-z

Fig. 6.

Fig. 6

Response time courses for transit compartments models with an increasing number of compartments. a Stimulation of kin0 (Eqs. 9, 1, 2). b Inhibition of kin0 (Eqs. 10, 1, 2). c Stimulation of n/TR (Eqs. 7, 1, 2). d Inhibition of n/TR (Eqs. 8, 1, 2). The bold curves are solutions of the basic lifespan based indirect response model: a Stimulation of kin0 (Eqs. 9 and 35). b Inhibition of kin0 (Eqs. 10 and 35). c Stimulation of n/TR (inhibition of TR) (Eqs. 7 and 30). d Inhibition of n/TR (stimulation of TR) (Eqs. 8 and 30). The parameter values used for simulations are the same as for Fig. 2, except for Dose = 10,000, and n = 1, 2, 3, 4, 5, 10, 20, 100