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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2010 Nov 24;38(2):179–204. doi: 10.1007/s10928-010-9183-z

Table 1.

Percent difference between the transit compartments model response Rn(t) and the limit lifespan based indirect model response R(t) for four models

n Stimulation of kin0 Inhibition of kin0 Stimulation of n/TR Inhibition of n/TR
1 75.3 76.1 64.7 77.5
2 52.5 53.2 42.1 63.1
3 42.9 43.7 32.9 57.8
4 37.2 37.9 27.8 54.9
5 33.5 33.8 24.4 53.0
10 23.6 24.4 16.4 47.9
20 16.4 16.9 11.2 43.9
100 6.5 7.8 4.7 35.4

The difference was evaluated at as the maximum absolute difference between Rn(t) and R(t) relative to the maximum absolute difference between R(t) and R0:maxt0Rn(t)R(t)maxt0R(t)R0×100.

The model parameters are as in Fig. 6