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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Diabetes Obes Metab. 2011 Nov;13(11):990–1000. doi: 10.1111/j.1463-1326.2011.01431.x

Figure 2.

Figure 2

GLP1-R immunoreactivity in mouse sciatic nerve. GLP1-R immunoreactivity is present in axons (A and B, arrowheads) and also in Schwann cell cytoplasm, where it is evident as perinuclear staining (brown reaction product surrounding the hematoxylin-counterstained Schwann cell nuclei) and signet ring profiles when Schwann cell nuclei are not in the plane of section (arrows in B). Note the lack of staining in the blood vessel or its cellular components subjacent to the epineurium (asterix in A). Inset in A: specificity of immunostaining demonstrated by omission of primary antibody. Inset in B: positive control showing GLP1-R immunoreactivity in an islet of Langerhans of the pancreas. Bar = 40 μm.