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. Author manuscript; available in PMC: 2012 Oct 25.
Published in final edited form as: Virology. 2011 Sep 9;419(2):72–83. doi: 10.1016/j.virol.2011.08.009

Figure 8. Effects of macropinocytosis and dynamin inhibitors on EBOV GP-dependent infection in monocytes and dendritic cells.

Figure 8

(A) Inhibitors of macropinocytosis and dynamin reduce VSV-GPΔMuc infection in the Jaws murine dendritic cell line. Jaws cells were pre-treated with 1% DMSO, 60 μM dynasore, 25 μM EIPA, 2.5 μM rottlerin, 0.01 μM latrunculin A, 5 μM ML9, or 50 μM blebbistatin and then exposed to VSV-GPΔMuc or VSV-G. Infection was scored by counting eGFP-positive cells. (B) Effects of dynasore and EIPA on infection by VSV-GP-FL and VSV-GPΔMuc in adherent PBMCs. CD14-positive PBMCs were pre-treated with 0.5% DMSO, 60 μM Dynasore, 25 μM EIPA, or 300 μM E-64d, and then exposed to virus. Infection was scored by counting eGFP-positive cells. (A-B) Means +/-SD of three replicates are shown.