Table 2.
Laboratory values of infants 0-90 days of age at enrollment in the PALF Study by etiology of acute liver failure.
| Metabolic N=20 | NH=20 | Viral Infection N=24 | Indeterminate N= 26 | Other N=20 | p-value (Wilcoxon) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Median (25%, 75%) | N | Median (25%, 75%) | N | Median (25%, 75%) | N | Median (25%, 75%) | N | Median (25%, 75%) | ||
| ALT (IU/L) | 20 | 117 (68, 213) | 16 | 35 (29,44) | 18 | 618 (377,993) | 42 | 109 (41,339) | 15 | 483 (321,1896) | <0.0001 |
| AST (IU/L) | 24 | 159 (72, 290) | 16 | 84 (57,143) | 23 | 2863 (847, 6150) | 52 | 153 (63,677) | 18 | 1066 (244, 2749) | <0.0001 |
| GGT (IU/L) | 24 | 55.5 (37.5, 102) | 15 | 23.0 (15.0, 33.0) | 19 | 110.0 (97.0,143) | 51 | 43.0 (26.0, 80.0) | 12 | 106.0 (82.0, 180.5) | <0.0001 |
| Total Bilirubin (mg/dL) | 27 | 13.9 (7.2, 18.6) | 17 | 12.2 (8.6, 162) | 20 | 7.9 (3.5, 10.0) | 54 | 15.2 (7.6, 19.6) | 19 | 10.6 (3.4, 15.9) | 0.03 |
| Direct Bilirubin (mg/dL) | 22 | 5.1 (2.6, 8.5) | 15 | 3.8 (2.3, 6.3) | 15 | 2.0 (1.1, 4.6) | 39 | 7.5 (2.6, 8.5) | 14 | 5.8 (2.2, 10.0) | 0.004 |
| PT (sec) | 21 | 22.7 (21.7, 24.8) | 16 | 29.1 (23.3,40.5) | 19 | 30.6 (26.0, 42.9) | 43 | 28.0 (21.8, 46.2) | 14 | 25.0 (21.0, 32.5) | 0.03 |
| INR | 20 | 2.5 (2.6,2.8) | 16 | 2.8 (2.0, 3.8) | 24 | 3.9 (2.8, 5.2) | 45 | 2.8 (2.0, 4.0) | 17 | 2.6 (1.8, 3.5) | 0.03 |
| BUN (mg/dL) | 18 | 4.0 (2.0,5.0) | 15 | 4.0 (2.0, 5.0) | 20 | 11.0 (8.5,17.0) | 38 | 7.9 (4.0, 12.0) | 17 | 23.0 (11.0, 30.0) | <0.0001 |
| Creatinine (mg/dL) | 26 | 0.4 (0.3,0.6) | 15 | 0.3 (0.3, 0.5) | 24 | 0.7 (0.4, 1.0) | 53 | 0.4 (0.3, 0.6) | 20 | 0.6 (0.4, 1.1) | 0.004 |
NH: Neonatal Hemochromatosis
Of note, the p values presented in this table represent multiple comparisons between the 5 potential etiologies for acute liver failure.