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. Author manuscript; available in PMC: 2012 Sep 19.
Published in final edited form as: Chem Res Toxicol. 2011 Aug 2;24(9):1527–1539. doi: 10.1021/tx200140s

Scheme 1.

Scheme 1

Representive mechanisms of quinone-induced carcinogenesis through ROS generation and direct DNA modification via Michael addition. The structures are simplified so that representative species are seen. The major adenine adduct is shown here as an example for DNA depurinating adducts.