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. Author manuscript; available in PMC: 2011 Sep 22.
Published in final edited form as: Psychiatr Clin North Am. 2010 Mar;33(1):181–224. doi: 10.1016/j.psc.2009.12.001

Table 1.

Candidate Gene Studies from STAR*D and Genome-wide Association Studies of Treatment Responses to Antidepressants.

Author (Year) Drug Gene(s) Outcome Sample Size Key Finding(s)
Candidate gene studies from STAR*D
McMahon (2006) Citalopram 68 genes Efficacy 1,953 (split sample design) Association with 5-HTR2A
Hu (2007) Citalopram 5-HTT Efficacy
Remission
Tolerance
Adverse effects
1,775 Association with adverse effect burden
Kraft (2007) Citalopram 5-HTT Efficacy 1,914 No association
Paddock (2007) Citalopram 68 genes Efficacy 1,816 (full sample) Association with GRIK4
Peters (2008) Citalopram CYP2D6, CYP2C19, CYP3A4, CYP3A5, ABCB1 Efficacy
Tolerance
1,953 (split sample design) No associations
Lekman (2008) Citalopram FKBP5 Efficacy 1,809 Association with response
Cabanero (2009) Citalopram PDE11A, PDE1A, PDE9A Efficacy 1,914 No association
Domschke (2009) Citalopram BDNF Efficacy 1,914 No association
Perlis (2009) Citalopram 68 genes Sexual Dysfunction 1,473 Associations with GRIA3, GRIK2, GRIA1, GRIN3A
Genome-wide association studies
Laje (2009) Citalopram Illumina Human-1
Bead Chip
Treatment emergent suicidal ideation 180 Association with PAPLN
Garriock (2009) Citalopram Affymetrix 500K and 5.0 Efficacy 1,491 Suggestive associations with UBE3C, BMP7, RORA
Ising (2009) Antidepressants Illumina Human-1 and HumanHap300
Bead Chips
Efficacy 339 Association with a multifactorial SNP score