Table 1.

Clinical parameters in regard to the extent of cerebral microangiopathy.

Parameter (n)	Leukoaraiosis	Leukoaraiosis	Lacunes	Lacunes
	No + mild (48)	Moderate + severe (16)	0 + 1 (14)	2–5 + > 5 (50)
Mean age (years), ± SD	63 ± 11	68 ± 9	65 ± 9	64 ± 11
Lacunar lesions,% (n)	83 (40)	100 (16)
Leukoaraiosis,% (n)			57 (8)	82 (41)
SISCO, mean ± SD	50 ± 4	44 ± 9	49 ± 5	48 ± 7
MME, mean ± SD	28 ± 2	26 ± 4	28 ± 2	28 ± 3
ME, mean ± SD	17 ± 3	13 ± 3	16 ± 3	16 ± 3
Hyperlipidemia (history),% (n)	54 (26)	19 (3)	64 (9)	40 (20)
Hyperlipidemia (measurements)% (n)	71 (34)	56 (9)	71 (10)	66 (33)
Migraine,% (n)	29 (14)	38 (6)	14 (2)	36 (18)
Previous stroke (history),% (n)	25 (12)	56 (9)	7 (1)	40 (20)
Previous stroke (imaging),% (n)	75 (36)	100 (16)	14 (2)	100 (50)
Left ventricular hypertophy,% (n)	6 (3)	6 (1)	0 (0)	8 (4)
Hydrocephalus,% (n)	2 (1)	19 (3)	0 (0)	8 (4)
NIHSS, mean ± SD	3.4 ± 1.8	3.8 ± 2.0	3.0 ± 2.3	3.6 ± 1.7
Barthel index, mean ± SD	92.5 ± 17.8	89.7 ± 22.3	91.8 ± 25.2	91.8 ± 17.1
Rankin scale, mean ± SD	2.2 ± 1.2	2.3 ± 1.3	2.1 ± 1.2	2.2 ± 1.2
Retinopathy,% (n)	48 (23)	75 (12)	43 (6)	58 (29)
Hypertension (history),% (n)	71 (34)	69 (11)	86 (12)	66 (33)
Hypertension (measurements),% (n)	73 (35)	75 (12)	86(12)	70 (35)
Diabetes (history),% (n)	29 (14)	31 (5)	21 (3)	32 (16)
Diabetes (measurements),% (n)	40 (19)	50 (8)	36 (5)	44 (22)
Pack years, mean ± SD	22 ± 31	9 ± 11	13 ± 17	21 ± 30
Current smoking, n (%)	38 (18)	31 (5)	21 (3)	40 (20)
Alcohol (g/month), mean ± SD	259 ± 532	154 ± 354	229 ± 449	299 ± 509
BMI, mean ± SD	27 ± 5	26 ± 4	27 ± 5	27 ± 4
Atrial fibrillation,% (n)	13 (6)	13 (2)	21 (3)	10 (5)
Foramen ovale,% (n)	13 (6)	6 (1)	14 (2)	10 (5)
Pulsatility index, mean ± SD	1.06 ± 0.20	1.15 ± 0.19	1.03 ± 0.13	1.10 ± 0.21
Intima-media thickness, mean ± SD	0.08 ± 0.02	0.08 ± 0.01	0.08 ± 0.02	0.10 ± 0.01
Proteinuria,% (n)	15 (7)	6 (1)	7 (1)	14 (7)
Emotional incontinence,% (n)	6 (3)	19 (3)	14 (2)	8 (4)
BDI, mean ± SD	8 ± 6	10 ± 7	7 ± 5	8 ± 6