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. 2011 Apr 1;25(6):694–703. doi: 10.1038/eye.2011.69

Table 1. Major complications of needle blocks (modified from Kumar and Dowd)14.

Complications Mechanism Risk factors Incidence Prevention Treatment
Inadvertent subarachnoid anaesthesia (Brain–stem anaesthesia) Subject to debate but spread through optic nerve sheath or through the orbital foramina Placement of long needle into the apex 0.3–0.8% (retrobulbar) Unknown (peribulbar) Avoid using long needle Extensive cardiorespiratory support
Ocular perforation Direct needle entry into the globe through sclera Placement of needle angled towards the apex 3 : 4000 (retrobulbar block) 1 : 16 224 (peribulbar block) Attention to anatomy and appropriate technique Immediate ophthalmic opinion
Retrobulbar haemorrhage Damage to arterial or venous blood vessels behind the globe Elderly receiving, steroids, NSAID, aspirin 0.1–3% Limit insertion of needle <31 mm in the relatively avascular area Immediate oculocompression, ophthalmic opinion and decompression surgery if necessary
Globe ischaemia Interruption of blood flow Prolonged oculocompression Unknown Use pressure limiting oculocompression device Ophthalmic opinion
Optic nerve atrophy Direct damage to nerve, central retinal artery, or secondary to haemorrhage   Unknown Careful needle placement Ophthalmic opinion
Damage to the motor nerve of the inferior rectus and inferior oblique muscles Direct trauma to the nerve Insertion of needle at the junction of medial 2/3rd and lateral 1/3rd of inferior orbital margin Unknown Careful needle placement avoiding the nerve Ophthalmic opinion
Prolonged extraocular muscle malfunction Prolonged exposure of fine muscle fibres, injection of local anaesthetic agent into the muscle May be associated with non-use of hyaluronidase Unknown Proper placement of needle Ophthalmic opinion
Orbital swelling Infection Excessive dose of hyaluronidase Poor technique Unknown Aseptic technique Use of recommended dose of hyaluronidase Antibiotics, steroids ophthalmic opinion