Table 3. Mean score of objective signs in patients with refractory VKC before and after treatment with topical 0.005% tacrolimus eye drop.

Sign	Before	3 days	1 month	Final follow-up	P-value
Conjunctival hyperaemia	2.60±0.52	2.60±0.52	0.80±0.42	0.60±0.52	<0.001
Papillary hypertrophy	2.70±0.48	2.70±0.48	1.30±0.67	0.60±0.52	<0.001
Giant papillary conjunctivitis	1.10±1.45	1.10±1.45	0.40±0.52	0.20±0.42	0.05
Limbal hypertrophy	0.90±1.29	0.90±1.29	0.80±1.13	0.20±0.42	0.04
Corneal punctate epithelial erosions	1.10±1.20	1.10±1.20	0	0	0.02
Corneal pannus	0.80±1.23	0.80±1.23	0.50±0.85	0.30±0.48	0.10
Corneal stromal opacity	0.50±1.10	0.50±1.10	0.50±1.10	0.40±0.84	0.34