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. Author manuscript; available in PMC: 2012 Aug 17.
Published in final edited form as: J Am Chem Soc. 2011 Jul 22;133(32):12454–12457. doi: 10.1021/ja205440x

Scheme 2. Scope of the Cyclization.

Scheme 2

a) Reaction Conditions: 4, Y(OTf)3 (1 mol%), Et3N (1 equiv.), LiCl (2 equiv.), amine or malonate nucleophile (1.2 equiv.), THF, rt b) Reaction Conditions: 7, Cu(OTf)2 (10 mol%), pyrrolidine (1 equiv.), DMSO, rt