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. 2011 Sep 16;60(10):2465–2473. doi: 10.2337/db11-0112

FIG. 5.

FIG. 5.

A: PPARα mRNA levels in liver and WAT are similar between WT and Nrf2-KO mice on a long-term HFD. PPARα mRNA levels were measured by quantitative RT-PCR in liver and WAT of WT and Nrf2-KO mice (n = 8 for each genotype) fed an HFD for 180 days. The RT-PCR was performed in triplicate wells for each sample. Bars show means ± SEM. B: Nrf2 mRNA levels are elevated in the liver and WAT of mice fed an HFD for 180 days compared with an SD. Nrf2 mRNA levels were measured by quantitative RT-PCR in liver and WAT of WT mice fed an HFD or SD (n = 8 for each diet group). The RT-PCR was performed in triplicate wells for each sample. Bars show means ± SEM. *P < 0.01, **P < 0.0001.