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. 2011 Sep 16;60(10):2608–2616. doi: 10.2337/db10-1395

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 2. — Effects of organic nitrate treatment on endothelium-dependent and -independent vasodilation in diabetic rats. Vascular function was determined by isometric tension studies and relaxation in response to endothelium-dependent (ACh) (A) and endothelium-independent with requirement of bioactivation (GTN) (B) vasodilators. Data are shown for control (Ctr) (circles), diabetic (STZ) (squares), STZ+PETN (triangles), and STZ+ISMN (inverted triangles) animals. Data are the means ± SEM of 37–77 (ACh) and 40–88 (GTN) aortic rings from 10–22 animals per group. *P < 0.05 vs. control; #P < 0.05 vs. STZ.

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