FIG. 5.

Modified Belfiore ISI calculated from ipGTTs of plasma glucose and insulin concentrations (Belfiore ISI). Significantly reduced insulin sensitivity in A1AR^−/− mice compared with wild-type (Wt) controls on the standard diet (SD) at 8 weeks (w) (A1AR^−/−: n = 3; Wt: n = 4) and 20 weeks (A1AR^−/−: n = 6; Wt: n = 5). No difference in mice on the HFD (Wt: n = 7; A1AR^−/−: n = 5). Intragroup comparison: increasing age on the SD led to significantly lower index values in Wt and A1AR^−/− mice. No difference was seen between A1AR^−/− mice on the HFD at 20–22 weeks vs. the SD at 20 weeks. In contrast, in Wt mice HFD lowered ISI significantly. NS, nonsignificant.