Table 1. Mean rates of change for patients with progressive glaucoma as measured by CLSO, SLP (GDxVCC and GDxECC), and Stratus OCT.
| Imaging technology | Study | Parameter |
Mean rates of change |
AROC | |
|---|---|---|---|---|---|
| Progressors | Non-progressors | ||||
| CSLO | Alencar et al1 | RA average (mm2/year) | −0.0058 | −0.0073 | 0.51 (95% CI, 0.40–0.61) |
| Poli et al2a | RA average (mm2/year) | −0.0123 | NA | NA | |
| See et al3 | RA average (mm2/year) | −0.0053 | −0.0012 | NA | |
| GDxECC | Medeiros et al4 | TSNIT average (μm/year) | −0.95 | −0.17 | NA |
| Medeiros et al5 | TSNIT average (μm/year) | −1.24 | −0.34 | 0.89 (95% CI, 0.83–0.95) | |
| Grewal et al6b | TSNIT average (μm/year) | −1.11 | −0.41 | NA | |
| GDxVCC | Medeiros et al7c | TSNIT average (μm/year) | −0.70 | −0.14 | NA |
| Medeiros et al5d | TSNIT average (μm/year) | −0.46 | −0.15 | 0.65 (95% CI, 0.53–0.77) | |
| Alencar et al1 | TSNIT average (μm/year) | −0.65 | −0.11 | 0.81 (95% CI, 0.74–0.88) | |
| Stratus OCT | Medeiros et al8 | TSNIT average (μm/year) | −0.72 | −0.14 | 0.83 (95% CI, 0.72–0.92) |
| Leung et al9 | TSINT average (μm/year) | −3.30 (median) | NA | NA | |
Abbreviations: AROC, area under the receiver operating characteristic curve; ARP, atypical patterns of retardation; CI, confidence interval; CLSO, confocal scanning laser ophthalmoscopy; ECC, enhanced corneal compensation; NA, not applicable; OCT, optical coherence tomography; RA, rim area; SAP, standard automated perimetry; SLP, scanning laser polarimetry; TSNIT, temporal–superior–nasal–inferior–temporal.
a
Calculated for ‘converters' (defined as normal or ocular hypertensive subjects who progressed to glaucoma).
b
Progression was defined by the slope of the visual field index on SAP.
c
Included scans with ARP.
d
Excluded scans with ARP.