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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Mol Pharm. 2011 Jun 1;8(4):1090–1099. doi: 10.1021/mp100402n

Figure 2.

Figure 2

Toxicity of docetaxel conjugates toward cultured cells. DU145 (A), PC-3(B) prostate cancer cells and HUVECs (C) were exposed to the compounds for continuous 72 h. In pulse-chase experiments (D) DU145 cells were incubated with the compounds for 2 h only, washed with PBS and incubated in fresh growth medium for an additional 70 h. The legend for this plot indicates how long compounds were in contact with cell growth medium. All compounds were added to cells either immediately after dilution in cell growth medium (2 h) or after 16 h of pre-incubation in the same medium at 37°C (16 +2 h). The values of 3–4 independent experiments are presented as mean ± S.D. For sample characteristics see Table 1.