Table 1.
Characteristics of HPMA copolymer conjugates
| Polymer no. | Structure | Comonomer Feed Composition (mol %) | Est.Mw(kD)a | Mw/Mna | Hydrody-namic diameter(nm) | DOCb | RGDfKc | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HPMA | MA-GFLG-DOC | MA-GG-RGDfK | MA-Tyr | 3-MPA(SEC) | (QELS) | wt % | wt % | ||||
| P1 | P-(GFLG-DC) | 95.5 | 2.5 | - | 2 | 4 | 32.6 | 2.9 | 3.0 | 6.8 | - |
| P2 | P-(GFLG-DC-RGDfK) | 92.5 | 2.5 | 3 | 2 | 4 | 26.9 | 1.9 | 3.0 | 6.84 | 5.061 |
| P3 | P-(GFLG-DC) | 95.5 | 2.5 | - | 2 | 1 | 87.1 | 4.9 | 7.6 | 7.15 | |
a
Estimated by size exclusion chromatography (SEC)
b
Determined by HPLC
c
Determined by amino acid analysis