Table 4. Pathway analysis of putative transcription factors binding to the Wig-1 promoter using Panther (http://www.pantherdb.org) with P-values for human and mouse Wig-1 promoter.
| Pathway | P-value human | P-value mouse |
|---|---|---|
| Interleukin signaling | 3.08E-17 | 3.57E-16 |
| Insulin/IGF-protein kinase B | 4.14E-10 | 5.93E-09 |
| TGF-beta signaling | 3.13E-09 | 2.98E-08 |
| PI3 kinase | 4.67E-09 | 5.21E-08 |
| PDGF signaling | 8.01E-09 | 5.71E-09 |
| Oxidative stress | 1.47E-07 | 1.18E-07 |
| Ras | 1.34E-05 | 1.11E-05 |
| Toll-receptor signaling | 5.43E-05 | 4.66E-05 |
| Apoptosis signaling | 1.52E-04 | 1.27E-04 |
| Wnt signaling | 2.16E-04 | 1.69E-04 |
| Inflammation mediated by chemokines and cytokines | 4.99E-04 | 1.98E-03 |
| p53 pathway feedback loops 2 | 4.67E-03 | 4.27E-03 |
The pathway ‘unclassified' was omitted