Figure 1.
Effects of pretreatments with P. papatasi and P. duboscqi salivary extracts on OVA-induced immune inflammation. OVA-immunized and control (sham-immunized) mice were treated with PBS or SGE from P. papatasi (Papa) or P. duboscqi (Dub) vector (one salivary gland/i.v./animal) 48 h before i.p. challenge with PBS or OVA (10 μg). The neutrophil migration (A) and MIP-1α (B), TNF-α (C), and LTB4 (D) production were determined in the peritoneal exudates 6 h after challenge. Data are the mean ± sem and are representative of two different experiments with four (ELISA) to six (neutrophil migration) mice per group per experiment; #, P < 0.05, compared with control group and immunized mice challenged with PBS; *, P < 0.05, compared with the PBS-pretreated, OVA-immunized group and challenge with OVA (PBS+OVA).