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Direct effect of anti-SP-R210 antibodies on cytokine secretion. PBMC from five PPD– donors were cultured in the absence or presence of different IgGs (10 μg/ml) as indicated. After 48 h incubation, concentrations of TNF-α (A) and IL-10 (B) were measured in culture supernatants by sandwich ELISA. Mean values ± se are shown.
