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. 2011 Sep 22;6(9):e24245. doi: 10.1371/journal.pone.0024245

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Mantopoulos et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) DAPI (blue) and TUNEL (green) staining of attached or detached for 5 days retina sections. TUDCA treatment was started 24 hrs before RD induction and continued daily at a dose of 500 mg/kg/day. (B) Quantitative analysis of TUNEL positive cells 3 and 5 days after RD with or without daily TUDCA treatment (500 mg/kg/day, I.P.). (n = 6, p<0.05). (C) Quantitative data exhibiting the protective effect of TUDCA (500 mg/kg/day, I.P.) on ONL thickness preservation, 3 and 5 after RD. (n = 6, p<0.05). (D) Protective effects of TUDCA were seen even when TUDCA treatment was started 6 hours after RD induction. (n = 6, P<0.05).