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. 2011 Sep 22;6(9):e24349. doi: 10.1371/journal.pone.0024349

Figure 4. UPS targets proteins involved in translational silencing and synaptic structure in the amygdala.

Figure 4

Animals were trained to auditory and context fear conditioning and amygdala tissue was collected 60-min later [n = 10] and compared to naïve homecage [HC] animals [n = 10]. In all cases, crude synaptosomal membrane fractions were obtained, mixed with GST-S5a, and probed with antibodies against MOV10, Shank and NR2B [A]. The amount of polyubiquitinated MOV10 [B] and Shank [C] was increased in trained animals, suggesting potential control over protein synthesis initiation and synaptic restructuring. * denotes p<.05 from HC controls.