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. 2011 Sep 22;6(9):e24349. doi: 10.1371/journal.pone.0024349

Figure 6. Protein degradation is increased in the amygdala following the retrieval of auditory and context fear memories.

Figure 6

[A] Experimental design for B. Animals were trained to context fear conditioning on Day 1. The following day, they received a 90-sec reminder to the training context and amygdala tissue was collected in 30-min increments [n = 9 per group]. A separate group of animals was placed into a novel environment and tissue collected 60-min later [n = 7]. Tissue was then purified with GST-S5a. [B] There was a rapid increase in the amount of proteins targeted for degradation, which returned to basal levels within 2-hrs. [C] Experimental design for D. Animals were trained to auditory fear conditioning on Day 1. The following day, they received a 30-sec reminder to the auditory cue and amygdala tissue was collected in 30-min increments [n = 9-10 per group]. Tissue was then purified with GST-S5a. [D] There was a delayed increase in the amount of proteins targeted for degradation, which returned to basal levels within 2-hrs. * denotes p<.05 from controls.