Table 4.

Toxic effects occurring during treatment of advanced breast cancer with PLD (described in at least 2 PLD-treated patients).

Toxic effects	N (%)
PPE	22 (17)
Grade 1	11 (9)
Grade 2	9 (7)
Grade 3	1 (1)
Exanthema	18 (14)
Mucositis	16 (12)
Nausea/Vomiting	12 (9)
Fatigue	11 (9)
Infectious event	12 (9)
Alopecia (only grade 1 and 2)	7 (5)
Gastrointestinal problems	6 (5)
Respiratory problems	5 (4)
Cardiac problems*	5 (4)
Neutropenia grade 4	3 (2)
Thrombocytopenia grade 4	2 (2)
Thromboembolic event	2 (2)
Cough	2 (2)
Hypersensitivity reaction	2 (2)

*Including 2 patients with severe congestive heart failure, one case of which was fatal. 4 patients with cardiac adverse events during PLD therapy harboured 2 cardiac risk factors, whereas the one patient with fatal exacerbation of heart failure was characterized by 5 cardiac risk factors.