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. 2011 Sep 22;6(9):e24901. doi: 10.1371/journal.pone.0024901

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Devbhandari et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Kaplan-Meier analysis revealed that patients with high CD151 expression had poor prognosis in terms of overall survival (A) and recurrence rate (B). However, no difference in overall survival (C) and recurrence rate (D) was observed between high integrin β1 expression group and low expression group. Patients were classified into four groups according to their CD151 and integrin β1 density: group I, high expression of both markers; group II, high expression of CD151 alone; group III, high expression of integrin β1 alone and group IV, low expression of both markers. Kaplan-Meier analysis revealed that HCC patients with overexpression of CD151/ integrin β1 presented with the worst overall survival (E) and the highest cumulative recurrence rate (F).