Figure 5. Percentages of structures built using single- and double-templates based on seven sequence alignment methods.

The percentages indicate the top five structures with lowest z scores for each target CBM are derived from either single-template or double-template homology modeling. The used alignment programs are FIA [21], MUSCLE [32], ClustalW2 [33], ProbCons [36], T-COFFEE [35], DIALIGN-TX [34], and MAFFT [37].