Figure 6. Receiver operating characteristic (ROC) curves of ligand-binding residue prediction.

97 known ligand-binding aromatic residues and 558 aromatic residues without experimental ligand-binding abilities in 49 template structures (see Supporting Information Table S2) are as positive and negative sets for prediction of ligand-binding aromatic residues, respectively. The ROC curves are generated by HAR-based and FRcons-lig [26] predictions.