Table 4. Genetic complexity at pre-treatment and 1 week after PEG-IFNα2b plus ribavirin combination therapy in immediate virologic responders and non-responders.

	Immediate virologic responders (N = 8)		Non-responders (N = 8)
	Pre-treatment	1 week after IFN therapy	Pre-treatment	1 week after IFN therapy
Mean number of aligned reads	263,452	356,963	256615	354,398
Mean number of aligned nucleotides	16,632,186	22,438,125	16,248,820	22,379,922
Mean coverage	1798	2416	1780	2461
Mutation frequency (%)	0.96	0.63	1.13	1.11
Shannon entropy	0.072*	0.049*	0.075**	0.066**

Wilcoxon rank sum test.

* p = 0.037.

** p = 0.12.