Table 3. Gene expressions in Bmal1 -/- mice.
Liver | Muscle | |||
ZT10 | ZT22 | ZT10 | ZT22 | |
Fatty acid binding and transpot | ||||
Cd36 | 2.7±0.3* | 1.1±0.1 | 1.2±0.2 | 1.4±0.2 |
Fabp5 | 4.3±0.4* | 1.5±0.1* | 1.1±0.1 | 0.9±0.2 |
Ldlr | 0.8±0.3 | 1.0±0.2 | 0.2±0.1* | 0.2±0.2* |
Lpl | 77.9±8.5* | 79.3±9.1* | 1.1±0.2 | 0.9±0.1 |
Srbi | 2.7±0.3* | 1.5±0.1* | 0.7±0.3 | 1.1±0.2 |
TG and fatty acid synthesis | ||||
Agat2 | 0.8±0.8 | 0.6±0.3 | 1.1±0.1 | 1.3±0.2 |
Agat3 | 1.0±0.2 | 1.1±0.1 | 2.0±0.2* | 1.8±0.2* |
Dgat1 | 0.6±0.2* | 0.7±0.1 | 0.9±0.2 | 1.1±0.1 |
Dgat2 | 0.5±0.1* | 0.5±0.1* | 0.6±0.2* | 0.4±0.2* |
Fasn | 0.3±0.0* | 0.3±0.0* | 6.3±0.6* | 1.1±0.2 |
Scd1 | 1.3±0.2 | 0.3±0.1* | 5.0±1.1* | 2.0±0.3* |
Fatty acid oxidation | ||||
Acaa 1a | 0.6±0.1* | 0.5±0.1* | 0.8±0.2 | 0.7±0.2 |
Acaa 1b | 0.3±0.1* | 0.2±0.0* | 0.6±0.3 | 0.6±0.3 |
Acadl | 1.7±0.2 | 0.7±0.2 | 1.6±0.2* | 0.9±0.2 |
Acadm | 0.7±0.3 | 0.7±0.2 | 1.7±0.3* | 1.3±0.1 |
Echdc1 | 0.6±0.1* | 0.5±0.1* | 1.3±0.3 | 0.9±0.1 |
Gene expressions in control mice and Bmal1 -/- mice were determined by RT-qPCR. Relative mRNA levels were normalized to the 36B4 level. Each value represented the mean fold-changes (± SEM) of Bmal1 -/- mice in comparison to control mice (n = 5 for each genotype and point). Asterisks indicate significant differences (P<0.05).