Figure 1. Expression of OAcGD2 and GD2 ganglioside antigens on peripheral nerves and neuroblastomas.

An immunoperoxydase assay was performed as described in Material and Methods. Strong immunostaining was detected on neuroblastoma cells (A) with either mAb 8B6 (2) or mAb 14G2a (3). No staining was observed on peripheral nerves (B) with mAb 8B6 specific for OAcGD2 (2). Myelin sheaths in the peripheral nerves (B) were strongly stained with mAb 14G2a against GD2 (3). The mouse IgG3 mAb negative control from AbD serotec (Oxford, UK) was used as a negative control (1). Scale bar  = 50 µm.