Table 3. Binding properties of mAbs 8B6 and 14G2a on tumor cell lines*.
Origin | Cell line | OAcGD2 expression (×106 /cell) | GD2 expression (×106 /cell) |
Human | |||
Neuroblastoma | IMR32 | 5.5 | 12.6 |
Small cell lung carcinoma | NCI-H69 | 0.16 | 0.19 |
Ovarina carcinoma | OVCAR-3 | 0.02 | 0.04 |
Mouse | |||
T lymphoma | EL4 | 0.53 | 0.74 |
Neuroblastoma | NXS2 | 0.52 | 1.3 |
Neuro 2a | 0 | 0 |
*Determined by Scatchard analyses using 125I-labelled mAb 8B6 or 125I-labelled mAb 14G2a.