Table 4.

Rate ratio (RR) of seminoma and non-seminoma testicular cancer according to site-specific familial cancer in first-degree relatives.

Cancer in first-degree relative (ICD-7)	seminoma testicular cancer			non-seminoma testicular cancer
	nca/nco	RR (95% CI)	p	nca/nco	RR (95% CI)	p
Buccal cavity and Pharynx (140–148)	9/23	0.81 (0.38–1.76)	0.60	11/17	1.28 (0.60–2.75)	0.52
Oesophagus (150)	12/13	1.87 (0.83–4.20)	0.13	5/6	1.77 (0.54–5.82)	0.35
Stomach (151)	12/22	1.11 (0.54–2.28)	0.77	7/13	1.07 (0.42–2.68)	0.89
Colorectal cancer (153–154)	55/117	0.95 (0.69–1.33)	0.78	36/72	1.00(0.66–1.51)	0.99
Liver (155.0)	2/5	0.79 (0.15–4.10)	0.78	5/6	1.66 (0.51–5.47)	0.40
Gallbladder (155.1)	2/4	1.09 (0.20–5.96)	0.93	1/4	0.54(0.06–4.89)	0.59
Pancreas (157)	19/28	1.37 (0.76–2.46)	0.29	12/17	1.38 (0.66–2.90)	0.39
Larynx (161)	3/15	0.41 (0.12–1.40)	0.15	4/13	0.59(0.19–1.83)	0.36
Lung (162.0,1)	68/141	0.99 (0.74–1.33)	0.94	52/108	0.96 (0.68–1.35)	0.80
Breast, female (170)a	74/147	1.02 (0.77–1.36)	0.89	61/111	1.10(0.80–1.52)	0.55
Female genital organs (171–176)a	46/106	0.87 (0.61–1.24)	0.45	32/71	0.90 (0.59–1.37)	0.63
Testis (178)
All male relativesb	39/13	6.43 (3.42–12.08)	<0.0001	30/13	5.40(2.69–10.83)	<0.0001
Fathersc	16/6	5.36 (2.10–13.70)	0.0005	14/7	4.00(1.62–9.92)	0.003
Brothersd	17/5	7.54 (2.77–20.54)	<0.0001	15/5	9.58 (2.75–33.41)	0.0004
Sonse	6/2	6.44 (1.30–31.93)	0.02	1/1	2.62 (0.16–42.15)	0.50
Other male genital organs (177,179)b	27/65	0.85 (0.54–1.33)	0.47	20/36	1.12 (0.64–1.94)	0.70
Kidney (180)	10/30	0.69 (0.33–1.41)	0.30	7/19	0.71 (0.29–1.73)	0.45
Bladder (181)	31/55	1.16 (0.74–1.82)	0.51	21/53	0.79 (0.48–1.33)	0.38
Melanoma of skin (190)	19/39	0.99 (0.57–1.73)	0.98	17/31	1.14 (0.63–2.08)	0.67
Brain and nervous system (193)	15/34	0.92(0.50–1.70)	0.80	20/23	1.91 (1.01–3.58)	0.05
Connective tissue (197)	3/8	0.78(0.21–2.93)	0.71	5/6	1.61 (0.49–5.30)	0.43
Non-Hodgkin lymphoma (200,202)	21/24	1.76 (0.97–3.18)	0.06	14/17	1.70 (0.84–3.46)	0.14
Hodgkin’s disease (201)	4/9	0.90 (0.28–2.92)	0.85	2/10	0.43 (0.09–1.97)	0.28
Multiple myeloma (203)	7/10	1.45 (0.55–3.83)	0.45	4/5	1.62 (0.43–6.06)	0.47
Leukemia (204)	14/30	0.96 (0.51–1.82)	0.90	9/12	1.40 (0.59–3.33)	0.45

n_ca: number of cases with the particular cancer in the family

n_co: number of controls with the particular cancer in the family

p: P-value

RR: rate ratio

95 % CI: 95 percent confidence interval

All analyses were adjusted for number of known first-degree relatives, unless otherwise stated

The numbers in the table do not add up, because cancer in relatives was only noted as ‘yes’ (for one or more cases) or ‘no’.

^aadjusted for number of known female first-degree relatives

^badjusted for number of known male first-degree relatives

^cadjusted for identification of father or not

^dadjusted for number of known brothers

^eadjusted for number of known sons