Table 3.
Univariate predictors of receiving adjuvant combined chemoradiation therapy among the 1,023 subjects who underwent gastrectomy.
Covariate | Chemoradiation therapy (%) |
Odds Ratio (95% CI) |
p-value | |
---|---|---|---|---|
Age at diagnosis (per year increase) | 30.2 | 0.88 (0.85, 0.90) | <0.0001 | |
65 to 75 | 45.7 | 1.0 | --- | |
75 to 85 | 22.1 | 0.34 (0.25, 0.45) | <0.0001 | |
85 and older | 3.3 | 0.04 (0.02, 0.11) | <0.0001 | |
Gender | ||||
Male | 33.3 | 1.39 (1.06, 1.83) | 0.0165 | |
Female | 26.4 | 1.0 | --- | |
Race | ||||
White | 30.1 | 1.0 | --- | |
Asian | 36.4 | 1.33 (0.94, 1.88) | 0.1089 | |
Other (including black) | 21.2 | 0.63 (0.39, 1.01) | 0.0542 | |
SES Quintile (per quintile increase) | 30.2 | 1.13 (1.03. 1.24) | 0.0097 | |
Six month diagnosis block (per 6 month increase) | 1.10 (1.02, 1.19) | 0.0161 | ||
Early 2000 | 20.6 | 1.0 | --- | |
Late 2000 | 33.8 | 1.96 (1.21, 3.17) | 0.0061 | |
Early 2001 | 29.6 | 1.62 (1.01, 2.61) | 0.0478 | |
Late 2001 | 29.7 | 1.63 (0.99, 2.68) | 0.0555 | |
Early 2002 | 36.4 | 2.20 (1.38, 3.51) | 0.0010 | |
Late 2002 | 32.2 | 1.82 (1.13, 2.94) | 0.0135 | |
T category | ||||
T1 | 38.0 | 1.0 | --- | |
T2 | 27.0 | 0.60 (0.33, 1.10) | 0.0977 | |
T3/T4 | 35.4 | 0.89 (0.48, 1.66) | 0.7209 | |
N category | ||||
N0 | 13.3 | 1.0 | --- | |
N1 | 35.8 | 3.64 (2.47, 5.36) | <0.0001 | |
N2 | 41.8 | 4.69 (2.96, 7.45) | <0.0001 | |
N3 | 56.8 | 8.60 (4.34, 17.07) | <0.0001 | |
Grade | ||||
1 | 25.0 | 1.0 | --- | |
2 | 26.3 | 1.07 (0.44, 2.61) | 0.8860 | |
3/4 | 32.2 | 1.43 (0.60, 3.40) | 0.4254 | |
Charlson comorbidity score (per score increase) | 30.2 | 0.81 (0.71, 0.93) | 0.0019 | |
0 | 32.0 | 1.0 | --- | |
1 | 35.2 | 1.15 ( 0.85, 1.56) | 0.3600 | |
2+ | 16.6 | 0.42 ( 0.27, 0.65) | 0.0001 | |
Gastrectomy at teaching hospital | ||||
Yes | 30.8 | 1.06 (0.81, 1.39) | 0.6554 | |
No | 29.5 | 1.0 | --- | |
Distance to RT facility (per additional mile) | 1.00 (1.00, 1.00) | 0.1032 | ||
Less than 45 | 29.6 | 1.34 (0.85, 2.11) | 0.2118 | |
45 or more | 36.0 | 1.0 | --- | |
SEER Region | ||||
Northeast | 29.6 | 0.85 (0.62, 1.17) | 0.3287 | |
South | 25.4 | 0.69 (0.45, 1.06) | 0.0918 | |
Midwest | 24.5 | 0.66 (0.41, 1.07) | 0.0893 | |
West | 33.0 | 1.0 | --- |
Abbreviations: SES=socioeconomic status, T=tumor, N=lymph node, RT=radiation therapy.