Table I.

Neutrophil infiltration into various organs following renal ischemia-reperfusion injury

		# neutrophils/mg tissue
Group	Pre-treatment	Renal Injury	Kidney	Lung	Spleen
1	PBS	Sham	167 ±60	71 ±67	21518 ±7425
2	CBLB502	Sham	199 ±59	60 ±25	18526 ±11784
3	PBS	I/R	2093 ±481	79 ±32	44452 ±7452
4	CBLB502	I/R	1158 ±315	58 ±41	33494 ±7286

Groups of 5 C57BL/6 mice were subjected to bilateral occlusion of renal pedicles for 45 minutes with one group serving as the sham control. Groups of the mice were given PBS or 1 μg of CBLB502 i.v. 30 minutes before imposing renal ischemia. Kidneys, lungs and spleens were harvested 24 hours after reperfusion from each animal, were digested, and the infiltrating neutrophils were quantitated following staining with anti-Gr-1 antibody and flow cytometry analyses. Data are indicated as number of neutrophils per mg of target tissue ±standard deviation.