Table 1.

Candidate genes in loci linked to asthma and the intermediate phenotypes

Ig E, immunoglobulin E; ST, skin prick test; BHR, Bronchial hyper-reactivity; Eos, eosinophil; IL. interleukin; DPP10, dipeptidyl peptidase 10; CD, cell differentiation antigen; TGF-α, transforming growth factor-α; GM-CSF, granulocyte macrophage colony stimulating factor; ADRβ2, adrenergic receptor; GCR, glucocorticoid receptor; TNF-α, tumor necrosis factor-α; GPR, G-protein coupled receptor; TCR, T-cell receptor; TMOD, tropomyosin-binding protein; FCER1β, IgE binding receptor β; INFγ, interferon γ; SCF, stem cell factor; IGF1, insulin-like growth factor; STAT6, signal transducer and activator of transcript 6; NOS1, nitric oxide synthase 1; LTA4H, leukotriene A4 hydrolase; TPT1, tumor protein; transitional controlled 1; PHF11, PHD finger protein 11; PTGDR, prostaglandin D2 receptor; TCRα/δ, T-cell receptor α/δ; MCC, mutated in colorectal cancers; ADAM33, adhesion disintegrin and metalloprotease 33.

^*Indicates asthma-related genes identified by genome linkage analysis, positional cloning, and case-control studies.