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Linkage Association Studies in Familial Ménière’s Disease
| Gene locus | Ethnic | Candidate gene | Anticipation | Replication | Phenotype |
|---|---|---|---|---|---|
| 12p12.3 | Swedish | PIK3C2G | Y | No | MD, migraine |
| 14q11-11 | UK | None | Y | No | MD, migraine |
| DFNA9 - 14p11.2 | Belgium, Netherland | COCH | Y | Y | Sensorineural hearing loss and vestibular dysfunction |
| 5 | German | None | ? | No | MD, migraine. Bilateral 27% |
| Unknown | Brazilian | None | ? | No | MD and migraine |
| Unknown | Finnish | None | No | No | MD |
| 1q32.1-32.3 | Chilean- North Spain | SCLA45A3 | ? | No | MD |
