Table 3.
History of Candidate Gene Association Studies in Ménière’s disease. None of them were Replicated in an Independent Population
| Gene | Paper | Phenotype | Cases | Controls | Odds ratio | P value |
|---|---|---|---|---|---|---|
| HLA-DRB1*1201 | Koyama S et al. 1993 | Sporadic MD | 20 | … | … | 0,04 |
| COCH | Fransen E et al. 1999 | Familial MD | 23 | 119 | … | … |
| HLA-DRB1*09 | Meng X et al. 2001 | Sporadic MD | 60 | 85 | 0,2 | 0,01 |
| Antiquitin | Lynch M et al. 2002 | Familial MD | 9 | … | … | … |
| HLA-Cw*07 | Melchiorri L et al. 2002 | Sporadic MD | 41 | 101 | 3,6 | 6,9.E-3 |
| HLA-DRB1*0405 | Koo JW et al. 2003 | Sporadic MD | 41 | 226 | 8,51 | 0,006 |
| KCNE1 | Doi K et al. 2005 | Sporadic MD | 63 | 205 | NC | NC |
| KCNE3 | Doi K et al. 2005 | Sporadic MD | 63 | 237 | NC | NC |
| HLA-DRB1*1101 | Lopez-Escamez JA et al. 2007 | Sporadic MD | 80 | 250 | 3,65 | 0,029 |
| Alpha-adducin | Teggi R et al. 2008 | Sporadic MD | 28 | 48 | … | 0,0034 |
| HSP 70 | Kawaguchi S et al. 2008 | Sporadic MD | 49 | 100 | … | <0,001 |
| PARP-1 | Lopez-Escamez JA et al. 2009 | Bilateral MD | 80 | 371 | 7,33 | 0,012 |
| PTPN22 | Lopez-Escamez JA et al. 2010 | Bilateral MD | 52 | 348 | 2,25 | 0,04 |
| FcγRIIIa | Lopez-Escamez JA et al. 2011 | Sporadic MD | 156 | 626 | 1,49 | 0,054 |
| NOS1/NOS2A* | Gazquez I et al., 2011 | Sporadic MD | 381 | 667 | 0.89 | 0.56 |
*
A CCTTT microsatellite was initially associated in Galicia population, OR=0.37, corrected p=0.04.