Table 3.
Haplotype based association in acromegaly patients and control II sample.
| Haplotype frequency (number) | |||||
|---|---|---|---|---|---|
| Names | Haplotypesa | Cases | Control II | OR (95% CI) | P valuesb |
| Hap1 | C-T-G | 0.385 (37) | 0.562 (534) | Ref | Ref |
| Hap2 | C-C-G | 0.260 (25) | 0.293 (279) | 1.3 (0.76–2.2) | 0.3358 |
| Hap3 | C-C-A | 0.188 (18) | 0.096 (91) | 2.85 (1.56–5.22) | 0.0016 |
| Hap4 | T-C-G | 0.146 (14) | 0.045 (43) | 4.69 (2.35–9.34) | 0.000053 |
| Hap5 | C-T-A | 0.021 (2) | 0.002 (2) | NC | NC |
| Hap6 | T-T-G | 0 (0) | 0.001 (1) | NC | NC |
OR, odds ratio; CI, confidence interval; Ref, reference group; NC, not calculated; association results for haplotypes with P<0.05 are marked with bold.
a
SNP order=rs34037914 – rs169068 – rs642249.
b
P value from Fisher exact test.