Table 2.

Neurochemical Evidence of Presynaptic Effect of Adenosine on Transmitter Release in the CNS

	Transmitter Release	Effect	Receptor Mediated	Reference
Cerebral cortex	ACh	inhibition	A1	[5, 158]
		facilitation	A2A	[166, 167]
Hippocampus	GABA	facilitation	A2A	[101]
	ACh	facilitation inhibition	A2A A1	[92, 94]
	NA	inhibition	A1	[93, 99]
	Glutamate	inhibition	A1	[168]
Striatum	Glutamate	inhibition	A1	[169]
	5-HT	inhibition	A1	[170]
	GABA	inhibition	A2A	[103]
	ACh	no effect inhibition	A2A A1	[93]
	DA	inhibition no effect	A1 A2A	[93, 105, 171]